Not known Factual Statements About phenobarbital sodium drug class
Not known Factual Statements About phenobarbital sodium drug class
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pentobarbital will lessen the level or effect of amlodipine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.
pentobarbital will decrease the level or effect of nisoldipine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
pentobarbital will lessen the extent or effect of bosentan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Not known.
pentobarbital will lower the extent or effect of linagliptin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Utilization of alternative therapies is strongly recommended when linagliptin should be to be administered with a CYP3A4 inducer
pentobarbital will decrease the level or effect of pimavanserin by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor. Prevent coadministration if possible. Observe for lowered pimavanserin efficacy. An increase in pimavanserin dosage may be essential.
pentobarbital will minimize the level or effect of roflumilast by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration not advised; solid cytochrome P450 enzyme inducers minimize systemic exposure to roflumilast and may reduce the therapeutic effectiveness
pentobarbital improves toxicity of ifosfamide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on. CYP3A4 inducers may improve the metabolism of ifosfamide to its Lively alkylating metabolites.
pentobarbital decreases levels of elvitegravir/cobicistat/emtricitabine/tenofovir DF by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. May cause lack of virologic reaction and possible resistance.
pentobarbital will reduce the level or effect of diclofenac by affecting hepatic enzyme CYP2C9/10 metabolism. Minimal/Importance Mysterious.
Corticosteroids: Barbiturates show up to reinforce the metabolism of exogenous corticosteroids possibly from the induction of hepatic microsomal enzymes. Sufferers stabilized on corticosteroid therapy may perhaps require dosage adjustments if barbiturates are included to or withdrawn from their dosage program.
pentobarbital will lower the level or effect of piroxicam by affecting hepatic enzyme CYP2C9/ten metabolism. Minor/Importance Not known.
fentanyl intranasal and pentobarbital both equally increase sedation. Prevent or Use Alternate Drug. Restrict use to people for whom alternative therapy alternatives are inadequate
pentobarbital will decrease the extent or effect of elbasvir/grazoprevir by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. The therapeutic effect of elbasvir/grazoprevir might be minimized if coadministered with sturdy CYP3A inducers and it is consequently contraindicated.
Anticoagulants: Phenobarbital lowers the plasma amounts of pentobarbital sodium contraindications dicumarol (name Earlier used: bishydroxycoumarin) and causes a reduce in anticoagulant action as measured from the prothrombin time. Barbiturates can induce hepatic microsomal enzymes causing amplified metabolism and lessened anticoagulant response of oral anticoagulants (e.